Psychoactive drugs on brain acetylcholine (Ach) levels in rats.

نویسنده

  • S B Gupta
چکیده

The level oftotal Ach in the brain has been shown to vary with the functional activity of the central nervous system. Such variation has been related to physiological changes in nervousactivity. such as sleep or wakefulness. which causes increase in Ach content in the brain tissue (1). Neuropharmacological agents also changed the Ach content (2.3.4.5). .• , Thepurpose of the present study was the quantititive determination of total Ach content in • the whole brain tissue of the rat under the effect of chlorpromazine (CPZ). trifluoperazine (TAl). imipramine (IMI) and methylamphetamine (M-AMP).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P 25: The Facilitatory Action of Snake Venom Phospholipase A2 Neurotoxins by Which Increase the Release of Acetylcholine, May Improve Alzheimer\'s Disease Symptoms

Introduction: In a serious brain disorder like Alzheimer's disease, the levels of acetylcholine (Ach) drop significantly. The gradual death of cholinergic brain cells leads to a profound loss of memory and learning ability. Acetylcholine is the chemical messenger that sends messages from one neuron to another in the area of the brain used for memory. Many of the current medications act to enhan...

متن کامل

Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats.

M.R. VASKO, L.E. DOMINO and E.F. DOMINO, Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats, European J. Pharmacol. 27 (1974) 145-147. Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted an...

متن کامل

Modulation of brain acetylcholine levels with cholinesterase inhibitors as a treatment of Alzheimer disease.

The author's hypothesis is that adequate acetylcholine (ACh) hydrolysis inhibition acting through a physiological mechanism could maintain levels of the neurotransmitter sufficient to stimulate postsynaptic receptors which are still active in the brain of patiens affected by senile dementia of Alzheimer type (SDAT). We postulate that the use of reversible and specific cholinesterase inhibitors ...

متن کامل

Dietary supplementation with uridine-5'-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat.

The biosynthesis of brain membrane phosphatides, e.g., phosphatidylcholine (PtdCho), may utilize three circulating compounds: choline, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); moreover, oral administration of the uridine source uridine-5'-monophosphate (UMP) can significantly increase levels of the phosphatides throughout the rodent brain. Si...

متن کامل

Acetylcholinesterase Inhibitors Are Neither Necessary nor Desirable for Microdialysis Studies of Brain Acetylcholine

Acetylcholine (ACh) is important in normal brain function as well as mental illness. Specifically, ACh is of interest in cognitive dysfunction in Alzheimer’s disease and schizophrenia (1), and possibly also negative and positive symptoms in schizophrenia (2). In vivo measurement of brain ACh is also important to animal studies of drugs, e.g. antipsychotic drugs (APDs) to treat Alzheimer’s disea...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Indian journal of physiology and pharmacology

دوره 24 1  شماره 

صفحات  -

تاریخ انتشار 1980